Super‐resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement
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چکیده
منابع مشابه
Podocyte foot process effacement as a diagnostic tool in focal segmental glomerulosclerosis.
Podocyte foot process effacement is characteristic of proteinuric renal diseases. In minimal change nephrotic syndrome (MCNS) foot processes are diffusely effaced whereas the extent of effacement varies in focal segmental glomerulosclerosis (FSGS). Here we measured foot process effacement in FSGS and compared it to that in MCNS and in normal kidneys. A clinical diagnosis was used to differentia...
متن کاملInhibition of podocyte FAK protects against proteinuria and foot process effacement.
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that plays a critical role in cell motility. Movement and retraction of podocyte foot processes, which accompany podocyte injury, suggest focal adhesion disassembly. To understand better the mechanisms by which podocyte foot process effacement leads to proteinuria and kidney failure, we studied the function of FAK in podocytes. In mur...
متن کاملCorrelation between Podocyte Foot Process Effacement and Proteinuria in Human Glomerular Diseases
The podocyte is a specialized epithelial cell with numerous interdigitating foot processes which play an important role in the regulation of the glomerular basement membrane (GBM) permeability. The nephrotic syndrome results from increased glomerular permeability to proteins and is structurally belived to be associated with podocyte foot process effacement. Despite increasing knowledge of the m...
متن کاملThe Structural and Functional Organization of the Podocyte Filtration Slits Is Regulated by Tjp1/ZO-1
Blood filtration in the kidney glomerulus is essential for physiological homeostasis. The filtration apparatus of the kidney glomerulus is composed of three distinct components: the fenestrated endothelial cells, the glomerular basement membrane, and interdigitating foot processes of podocytes that form the slit diaphragm. Recent studies have demonstrated that podocytes play a crucial role in b...
متن کاملPodocytes are firmly attached to glomerular basement membrane in kidneys with heavy proteinuria.
Glomerular epithelial cells (podocytes) play an important role in the pathogenesis of proteinuria. Podocyte foot process effacement is characteristic for proteinuric kidneys, and genetic defects in podocyte slit diaphragm proteins may cause nephrotic syndrome. In this work, a systematic electron microscopic analysis was performed of the structural changes of podocytes in two important nephrotic...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2021
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.16519